ITGA1 — Integrin subunit alpha 1
ITGA1 belongs to a gene co-expression module in 10 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
ITGA1's module in each cell type
About the gene
| Synonyms | CD49a, VLA1 |
|---|---|
| Chromosome | 5: 52787916-52959209 |
| Predicted location | Membrane |
| Essential gene | No |
| Protein class | Cancer-related genes, CD markers, Plasma proteins, Predicted membrane proteins, Transporters |
| Molecular function | Integrin, Receptor |
| Biological process | Cell adhesion |
Function
Integrin alpha-1/beta-1 is a receptor for laminin and collagen. It recognizes the proline-hydroxylated sequence G-F-P-G-E-R in collagen. Involved in anchorage-dependent, negative regulation of EGF-stimulated cell growth
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.