NK Receptor Expression
Gene co-expression module in Gamma-delta T cells
| Category | cytotoxicity |
|---|---|
| Genes | 13 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 7 of 13 genes have a known function matching the annotation |
Why this annotation
Top hub genes KLRC2 (NKG2C) and KLRC3 (NKG2E) are NK lectin-like receptors strongly expressed on innate-like and CMV-adapted T cells. KIR2DL4 is an NK killer immunoglobulin receptor. Together these define an NK-receptor-high gd T cell subset with innate cytotoxic character. PTPN22 modulates TCR/NK signaling thresholds. CRACR2B regulates calcium signaling in lymphocytes. GPR55 and GPR171 are GPCRs expressed on NK/innate-like T cells. PLAGL1 is a transcriptional regulator. This tightly co-expressed core module (all core membership) represents innate NK-receptor expression in gd T cells.
Genes
CRACR2B, GFOD1, GPR171, GPR55, GSTM4, KIR2DL4, KLRC2, KLRC3, MORF4L2, NAP1L4, PARD6A, PLAGL1, PTPN22
Most correlated modules
- Activation Stress Response · correlation 0.92
- Tissue Resident CD103+ · correlation 0.92
- Gut-homing Residence · correlation 0.91
- Chromatin Repression · correlation 0.90
- Hypoxia Tissue Adaptation · correlation 0.89
- T Cell Exhaustion · correlation 0.88
- mRNA Splicing Regulation · correlation 0.86
- Chromatin Remodeling Signaling · correlation 0.84
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.