TRGC1 — T cell receptor gamma constant 1
TRGC1 belongs to a gene co-expression module in 5 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
TRGC1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | Gamma-delta T cell Cell contamination | ABHD15, ANKRD28, APOBR, CLIC3, CLIC5, EGLN3, ELOVL6, GLO1 +9 more | View in SCUBA |
| CD8⁺ T cells | IEL Gut Residence Gut residence | HOPX, ITGA1, KLRC1, KLRC2, KLRD1, LAT2, SPRY1, TRDC +1 more | View in SCUBA |
| Innate lymphoid cells | NK Cytotoxic Regulation Cytotoxicity | ARHGAP30, BIN2, CAPN12, CHD9, CLK1, CTSC, CYB5B, DDX27 +29 more | View in SCUBA |
| Monocytes | TNF/IL-1 Cytokine Storm Inflammatory | CCL3, CCL4, CCL4L2, EGR3, IL1A, IL6, KCNJ2, PTGS2 +3 more | View in SCUBA |
| Natural Killer cells | NK Cytotoxic Signaling Cytotoxicity | APOBEC3G, B2M, CALM1, CD48, GLIPR2, HCST, MYL12A, TMSB10 +1 more | View in SCUBA |
About the gene
| Synonyms | C1, TCRGC1 |
|---|---|
| Chromosome | 7: 38257879-38265678 |
| Predicted location | Membrane |
| Essential gene | No |
| Protein class | Predicted membrane proteins, T-cell receptor genes |
Function
Constant region of T cell receptor (TR) gamma chain that participates in the antigen recognition. Gamma-delta TRs recognize a variety of self and foreign non-peptide antigens frequently expressed at the epithelial boundaries between the host and external environment, including endogenous lipids presented by MH-like protein CD1D and phosphoantigens presented by butyrophilin-like molecule BTN3A1. Upon antigen recognition induces rapid, innate-like immune responses involved in pathogen clearance and tissue repair. Binding of gamma-delta TR complex to antigen triggers phosphorylation of immunoreceptor tyrosine-based activation motifs (ITAMs) in the CD3 chains by the LCK and FYN kinases, allowing the recruitment, phosphorylation, and activation of ZAP70 that facilitates phosphorylation of the scaffolding proteins LCP2 and LAT. This lead to the formation of a supramolecular signalosome that recruits the phospholipase PLCG1, resulting in calcium mobilization and ERK activation, ultimately leading to T cell expansion and differentiation into effector cells. Gamma-delta TRs are produced through somatic rearrangement of a limited repertoire of variable (V), diversity (D), and joining (J) genes. The potential diversity of gamma-delta TRs is conferred by the unique ability to rearrange (D) genes in tandem and to utilize all three reading frames. The combinatorial diversity is considerably increased by the sequence exonuclease trimming and random nucleotide (N) region additions which occur during the V-(D)-J rearrangements.
Human Protein Atlas · Open Targets
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.