HOPX — HOP homeobox
HOPX belongs to a gene co-expression module in 7 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
HOPX's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD19⁺ B cells | BCR Ras signaling BCR/AP1/NFKb pathway | ANKRD28, CCL5, DOK3, GSTK1, GYPC, HSH2D, ITGAM, MCOLN2 +12 more | View in SCUBA |
| CD4⁺ T cells | Cytotoxic Effector CD4 Cytotoxicity | ADAM8, ADRB2, CCL5, CHD9, DPP4, HIC1, IFIT2, ITGA1 +13 more | View in SCUBA |
| CD8⁺ T cells | IEL Gut Residence Gut residence | ITGA1, KLRC1, KLRC2, KLRD1, LAT2, SPRY1, TRDC, TRGC1 +1 more | View in SCUBA |
| Fibroblasts | ICC niche interactaion Gut motility | ABCC9, ADGRF5, ANO1, CD36, CFHR1, ESAM, FHL5, HRH2 +10 more | View in SCUBA |
| Hematopoietic progenitor cells | Quiescent HSC State Stemness | ARHGEF17, BAALC, BIN1, CD52, GNAI1, MZB1, RBPMS, SPINK2 | |
| Innate lymphoid cells | NK Homing Circulating Homing & TEM | ADD3, ANXA1, APOBEC3G, C16orf54, C1orf162, CAPG, CASP4, CAST +37 more | View in SCUBA |
| Pericytes | Quiescent Pericyte State Developmental | ARID5B, C1QTNF1, CPE, ITGA7, LPP, MT2A, MTHFD2, SLIT3 +1 more | View in SCUBA |
About the gene
| Synonyms | HOP, LAGY, NECC1, OB1, SMAP31 |
|---|---|
| Chromosome | 4: 56647988-56681899 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins, Transcription factors |
| Molecular function | Developmental protein, Repressor |
| Biological process | Transcription, Transcription regulation |
Function
Atypical homeodomain protein which does not bind DNA and is required to modulate cardiac growth and development. Acts via its interaction with SRF, thereby modulating the expression of SRF- dependent cardiac-specific genes and cardiac development. Prevents SRF- dependent transcription either by inhibiting SRF binding to DNA or by recruiting histone deacetylase (HDAC) proteins that prevent transcription by SRF. Overexpression causes cardiac hypertrophy (By similarity). May act as a tumor suppressor. Acts as a co-chaperone for HSPA1A and HSPA1B chaperone proteins and assists in chaperone-mediated protein refolding.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.