KMT2B — Lysine methyltransferase 2B
KMT2B belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
KMT2B's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | Membrane Trafficking Protein processing & ER | B4GALT1, BTF3L4, CELF1, CLTC, CSNK1G3, CTBS, DERL2, DYNC1LI2 +23 more | View in SCUBA |
| Gamma-delta T cells | Chromatin-Splicing Regulation DNA/chromatin regulation | ANKRD11, BOD1L1, CAMLG, CEBPB, EAPP, FMR1, MED10, MFSD14A +13 more | |
| Macrophages | Transcriptional Elongation Housekeeping | AKIRIN1, ATF4, ATXN2L, CCDC82, CDK9, CHMP1A, CLCN7, EIF5 +19 more | View in SCUBA |
About the gene
| Synonyms | CXXC10, HRX2, KIAA0304, MLL1B, MLL2, MLL4, TRX2, WBP7 |
|---|---|
| Chromosome | 19: 35717973-35738880 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Cancer-related genes, Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins, Transcription factors |
| Molecular function | Chromatin regulator, DNA-binding, Methyltransferase, Transferase |
| Biological process | Transcription, Transcription regulation |
Function
Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) via a non-processive mechanism. Part of chromatin remodeling machinery predominantly forms H3K4me1 and H3K4me2 methylation marks at active chromatin sites where transcription and DNA repair take place. Likely plays a redundant role with KMT2C in enriching H3K4me1 marks on primed and active enhancer elements. Plays a central role in beta-globin locus transcription regulation by being recruited by NFE2. Plays an important role in controlling bulk H3K4me during oocyte growth and preimplantation development (By similarity). Required during the transcriptionally active period of oocyte growth for the establishment and/or maintenance of bulk H3K4 trimethylation (H3K4me3), global transcriptional silencing that preceeds resumption of meiosis, oocyte survival and normal zygotic genome activation (By similarity).
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.