Chromatin-Splicing Regulation
Gene co-expression module in Gamma-delta T cells
| Category | DNA/chromatin regulation |
|---|---|
| Genes | 22 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 11 of 22 genes have a known function matching the annotation |
Why this annotation
Hub genes include KMT2B (H3K4 methyltransferase), MED10 (Mediator complex subunit), PHF10 (BAF chromatin remodeling), ANKRD11 (chromatin regulator), SF3B6/SNU13/SYF2 (splicing factors), and EAPP (E2F-associated phosphoprotein). The module combines chromatin remodeling and transcriptional co-regulation machinery with pre-mRNA splicing factors, consistent with a coupled transcription-splicing regulatory program. Moderate coherence reflects the two related but distinct sub-programs (chromatin vs. splicing). Uniform expression across subsets indicates a housekeeping-level transcriptional regulatory program rather than a cell-state-specific response.
Genes
ANKRD11, BOD1L1, CAMLG, CEBPB, EAPP, FMR1, KMT2B, MED10, MFSD14A, NCBP2AS2, PHF10, PIP4K2A, RAB5IF, RBM3, RWDD1, SF3B6, SMIM26, SNU13, SPTY2D1, SYF2, ZNRF2, ZXDC
Most correlated modules
- Ubiquitin-p53 Regulation · correlation 0.82
- Histone Demethylase Program · correlation 0.78
- Polycomb Transcriptional Control · correlation 0.77
- RNA Surveillance/NMD · correlation 0.76
- GPCR-AKT-MAPK Signaling · correlation 0.75
- Chromatin Epigenetic Regulation · correlation 0.75
- Stress Epigenetic Silencing · correlation 0.74
- TCR Early Activation · correlation 0.74
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.