MED10 — Mediator complex subunit 10
MED10 belongs to a gene co-expression module in 6 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
MED10's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | Venous EC Identity Endothelial cell development | CAVIN2, CEACAM1, CYBA, DNMBP, EFCC1, EPHX1, GMFG, HID1 +7 more | View in SCUBA |
| Gamma-delta T cells | Chromatin-Splicing Regulation DNA/chromatin regulation | ANKRD11, BOD1L1, CAMLG, CEBPB, EAPP, FMR1, KMT2B, MFSD14A +13 more | |
| Innate lymphoid cells | Proteasome ER Proteostasis Protein processing & ER | ATP5MC1, ATP5PF, DBI, GNG5, GTF3C6, HNRNPK, IL4I1, MANF +19 more | View in SCUBA |
| Macrophages | ER Protein Translocation Vesicular traficking | ACADVL, ARRB2, BCL7B, BORCS7, DDRGK1, DEF8, DNAJB12, DVL3 +22 more | View in SCUBA |
| Mucosal-associated invariant T cell | Vesicular Trafficking Housekeeping | ATP5PO, ATP6V1G1, CALM1, EEF1G, GET4, KLF2, MZT2B, PSMD7 +5 more | |
| Natural Killer cells | Circadian NF-κB Crosstalk Inflammation | DUSP8, IRF2BP2, ISCA1, MAP3K8, PER1, RELB, RHOH, SLC7A5 | View in SCUBA |
About the gene
| Synonyms | L6, MGC5309, NUT2, TRG20 |
|---|---|
| Chromosome | 5: 6371874-6378571 |
| Predicted location | Intracellular |
| Essential gene | Yes |
| Protein class | Essential proteins, Predicted intracellular proteins |
| Molecular function | Activator |
| Biological process | Transcription, Transcription regulation |
Function
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.