LIPA — Lipase A, lysosomal acid type
LIPA belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
LIPA's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Macrophages | Innate Antiviral Sensing Innate immunity | ADA2, ADPRH, ALDH9A1, APOBEC3C, BST2, C2, CAT, CD4 +26 more | View in SCUBA |
| Monocytes | M2 Macrophage Polarization Tissue homeostasis | ABCC5, ADAP2, ARHGAP18, CD84, FRMD4B, GNPDA1, MAF, MRC1 | View in SCUBA |
| Pericytes | G1 Cell Cycle Entry Cell cycle | CCND3, CCNY, CPNE8, FKBP9, GRAMD1A, MAPK3, MGAT1, NCK1 +6 more | View in SCUBA |
About the gene
| Synonyms | CESD, LAL |
|---|---|
| Chromosome | 10: 89213569-89414557 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins |
| Molecular function | Hydrolase |
| Biological process | Lipid degradation, Lipid metabolism |
Function
Catalyzes the deacylation of cholesteryl ester core lipids of endocytosed low density lipoproteins to generate free fatty acids and cholesterol. Hydrolyzes triglycerides (1,2,3- triacylglycerol) and diglycerides (such as 1,2-diacylglycerol and 1,3- diacylglycerol) with preference for the acyl moieties at the sn-1 or sn-3 positions.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.