G1 Cell Cycle Entry
Gene co-expression module in Pericytes
| Category | Cell cycle |
|---|---|
| Genes | 15 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 6 of 15 genes have a known function matching the annotation |
Why this annotation
This module contains CCND3 (cyclin D3, G1/S transition), CCNY (cyclin Y, CDK16 activator), MAPK3 (ERK1, mitogenic signaling), NCK1 (adaptor linking receptor tyrosine kinases to downstream proliferative signals), and RALB (Ras-like GTPase involved in cell survival/proliferation). RILPL2 and LIPA suggest lysosomal activity. MGAT1 (N-glycosylation in ER/Golgi) and FKBP9 (ER folding) add ER processing context. The cyclin/MAPK axis is the most coherent functional theme, suggesting mild growth factor-driven cell cycle entry or G1 progression in a subset of pericytes. PCGF2 (polycomb) may regulate quiescence exit.
Genes
CCND3, CCNY, CPNE8, FKBP9, GRAMD1A, LIPA, MAPK3, MGAT1, NCK1, NDUFA12, PCGF2, RALB, RILPL2, SLFN5, TMEM243
Most correlated modules
- Vascular Junction Adhesion · correlation 0.98
- BMP Receptor Signaling · correlation 0.96
- Actin-ERM Migration · correlation 0.96
- RAS-Chromatin Signaling · correlation 0.95
- Vascular Pericyte Identity · correlation 0.95
- RAS Cytoskeletal Signaling · correlation 0.95
- YAP/TAZ Mechanosensing · correlation 0.95
- Golgi Vesicular Trafficking · correlation 0.94
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.