MGAT1 — Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase
MGAT1 belongs to a gene co-expression module in 7 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
MGAT1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | Inflammatory activation Immune regulation | ATF7IP2, ATP10D, B3GALT2, COMMD8, GBP3, GFI1, GPR34, MAEA +7 more | View in SCUBA |
| Endothelial | Caveolae-mediated Transcytosis Metabolite transfer | ADIPOR2, CAV1, CAV2, CCDC85A, CD320, EEPD1, EMP2, ENAH +19 more | View in SCUBA |
| Gamma-delta T cells | ER-Lysosomal Trafficking Protein processing & ER | ARL6IP5, ATF6B, BORCS6, CD53, CLN3, DHRS7, MMP23B, NAA40 +12 more | |
| Innate lymphoid cells | NK Cytotoxic Effector Cytotoxicity | ACAA2, APIP, B4GALNT1, CAMK4, CCL5, CCNG2, CD247, CD3E +17 more | View in SCUBA |
| Macrophages | RNA Processing Regulation Housekeeping | ACBD3, AQR, ARCN1, BFAR, BNIP3L, CCNI, CCNK, DIS3 +15 more | View in SCUBA |
| Mucosal-associated invariant T cell | Oxidative Stress Response Stress | ATIC, CD244, CYTH4, EIF2S2, GPR68, GSDMD, ING4, KEAP1 +11 more | |
| Pericytes | G1 Cell Cycle Entry Cell cycle | CCND3, CCNY, CPNE8, FKBP9, GRAMD1A, LIPA, MAPK3, NCK1 +6 more | View in SCUBA |
About the gene
| Synonyms | GLCNAC-TI, GLYT1, GNT-1, GnTI, MGAT |
|---|---|
| Chromosome | 5: 180784780-180815652 |
| Predicted location | Intracellular, Membrane |
| Essential gene | No |
| Protein class | Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins |
| Molecular function | Glycosyltransferase, Transferase |
Function
Initiates complex N-linked carbohydrate formation. Essential for the conversion of high-mannose to hybrid and complex N-glycans
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.