Immune Synapse Cytoskeleton
Gene co-expression module in Gamma-delta T cells
| Category | Cytoskeletal |
|---|---|
| Genes | 17 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 9 of 17 genes have a known function matching the annotation |
Why this annotation
Hub genes TMC8/TMC6 are expressed in immune cells and linked to immune evasion. PSTPIP1 is an actin-binding scaffold protein involved in immune synapse formation and cytoskeletal remodeling. ARHGAP4 and ARHGAP45 are Rho GTPase-activating proteins regulating actin dynamics. SEPTIN9 is a cytoskeletal septin involved in cell division and morphology. CD48 mediates NK/T cell adhesion. IL32 is a pro-inflammatory cytokine produced by T cells. ICAM3 is an adhesion molecule at the immune synapse. LTB4R2 (leukotriene B4 receptor) mediates chemotaxis. LAPTM5 is a lysosomal membrane protein in lymphocytes. The dominant theme is cytoskeletal remodeling and immune synapse organization, with supporting inflammatory/activation features.
Genes
ARHGAP4, ARHGAP45, ATP2A3, CD48, DDOST, ICAM3, IL32, LAPTM5, LTB4R2, MAN2B1, P4HB, PSTPIP1, RPN2, SEPTIN9, TMC6, TMC8, ZNF592
Most correlated modules
- Coinhibitory Checkpoint · correlation 0.93
- TCR-Cytokine Signaling · correlation 0.85
- TCR Proximal Signaling · correlation 0.84
- T-bet Effector Differentiation · correlation 0.84
- Naive T cell quiescence · correlation 0.82
- Effector Cell Migration · correlation 0.81
- Lymphocyte Homeostatic Regulation · correlation 0.80
- Cytotoxic Effector Program · correlation 0.79
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.