GULP1 — GULP PTB domain containing engulfment adaptor 1
GULP1 belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
GULP1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | EC Barrier Integrity Endothelial cell development | ABCB1, ADCY4, AQP3, ARHGAP31, CRYBG3, EPS8, FGR, FRYL +14 more | View in SCUBA |
| Pericytes | Pericyte ECM Secretion ECM production | ATP1A2, CPM, CSRP2, DACH1, EFEMP1, FRZB, MASP1, NDUFAF4 +3 more | View in SCUBA |
About the gene
| Synonyms | CED-6, CED6, GULP |
|---|---|
| Chromosome | 2: 188291669-188595931 |
| Predicted location | Intracellular, Membrane |
| Essential gene | No |
| Protein class | Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins |
| Biological process | Apoptosis, Lipid transport, Phagocytosis, Transport |
Function
May function as an adapter protein. Required for efficient phagocytosis of apoptotic cells. Modulates cellular glycosphingolipid and cholesterol transport. May play a role in the internalization and endosomal trafficking of various LRP1 ligands, such as PSAP. Increases cellular levels of GTP-bound ARF6.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.