Pericyte ECM Secretion
Gene co-expression module in Pericytes
| Category | ECM production |
|---|---|
| Genes | 12 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 11 of 12 genes have a known function matching the annotation |
Why this annotation
Key hub genes: FRZB (Wnt antagonist/secreted frizzled-related), PTN (pleiotrophin, heparin-binding growth factor), CSRP2 (cysteine-rich protein, smooth muscle/pericyte marker), DACH1 (developmental transcription factor), ATP1A2 (Na/K-ATPase alpha-2, pericyte/smooth muscle), SERPINI1 (neuroserpin/ECM serpin), OLFM2 (olfactomedin ECM), EFEMP1 (EGF-containing fibulin-like ECM), CPM (carboxypeptidase M, stromal), GULP1 (engulfment adaptor), MASP1 (complement/coagulation), NDUFAF4 (mitochondrial complex I assembly factor — somewhat discordant but may reflect metabolic coupling). The dominant theme is secreted ECM/matrix-associated proteins and pericyte-enriched factors. FRZB, PTN, EFEMP1, SERPINI1, OLFM2 are all secreted matrix-associated proteins. CSRP2 and ATP1A2 are pericyte/smooth muscle markers. This module represents a pericyte-specific ECM secretory program with Wnt-modulatory capacity.
Genes
ATP1A2, CPM, CSRP2, DACH1, EFEMP1, FRZB, GULP1, MASP1, NDUFAF4, OLFM2, PTN, SERPINI1
Most correlated modules
- Pericyte Identity · correlation 0.54
- Pericyte Identity · correlation 0.54
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.