EFEMP1 — EGF containing fibulin extracellular matrix protein 1
EFEMP1 belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
EFEMP1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Fibroblasts | Subepithelial Fibroblast Identity Developmental | ANGPTL1, APBB1IP, ARHGAP15, CNTN1, CP, ECM2, FAM107A, FGF13 +12 more | View in SCUBA |
| Pericytes | Pericyte ECM Secretion ECM production | ATP1A2, CPM, CSRP2, DACH1, FRZB, GULP1, MASP1, NDUFAF4 +3 more | View in SCUBA |
| Smooth muscle cells | Fibroblast-like Activation Activation | ANGPTL2, CTSK, LMO3, MICALL2, PDLIM4, PDPN, PTK7 | View in SCUBA |
About the gene
| Synonyms | DHRD, FBLN3, FBNL, MTLV, S1-5 |
|---|---|
| Chromosome | 2: 55865967-55924139 |
| Predicted location | Intracellular, Secreted |
| Essential gene | No |
| Protein class | Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins |
| Molecular function | Growth factor |
Function
Binds EGFR, the EGF receptor, inducing EGFR autophosphorylation and the activation of downstream signaling pathways. May play a role in cell adhesion and migration. May function as a negative regulator of chondrocyte differentiation. In the olfactory epithelium, it may regulate glial cell migration, differentiation and the ability of glial cells to support neuronal neurite outgrowth.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.