CPM — Carboxypeptidase M
CPM belongs to a gene co-expression module in 5 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
CPM's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | NFAT activation TCR/AP1/NFKb pathway | AHI1, ASAP1, BCAT1, BICDL1, CYP7B1, ETV6, FAM107B, FKBP5 +13 more | View in SCUBA |
| Macrophages | Macrophage Migration Migration & adhesion | CEMIP2, EPB41L2, EPS8, GBE1, ITGA9, KCNQ1, MAN1A1, MEF2C +12 more | View in SCUBA |
| Monocytes | Efferocytosis Tissue Macrophage Lysosomal & pahgocytosis | ADORA3, AKR1B1, FCHO2, GPR34, MERTK, PDK4, SLC1A3, STARD13 | View in SCUBA |
| Pericytes | Pericyte ECM Secretion ECM production | ATP1A2, CSRP2, DACH1, EFEMP1, FRZB, GULP1, MASP1, NDUFAF4 +3 more | View in SCUBA |
| Smooth muscle cells | Pericyte Signature Development | AC100803.3, CCND1, COX4I2, ENTPD3, GPR20, GPRIN3, GRIP2, ISYNA1 +8 more | View in SCUBA |
About the gene
| Chromosome | 12: 68842197-68971570 |
|---|---|
| Predicted location | Intracellular, Membrane |
| Essential gene | No |
| Protein class | Enzymes, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins |
| Molecular function | Carboxypeptidase, Hydrolase, Metalloprotease, Protease |
Function
Specifically removes C-terminal basic residues (Arg or Lys) from peptides and proteins. It is believed to play important roles in the control of peptide hormone and growth factor activity at the cell surface, and in the membrane-localized degradation of extracellular proteins
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.