MAST2 — Microtubule associated serine/threonine kinase 2
MAST2 belongs to a gene co-expression module in 1 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
MAST2's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Enterocytes | Apicobasal polarity scaffold Migration & adhesion | ADGRG7, CAMK2D, DPYD, MAGI3, MGAM2, NUMB, PATJ, PRELID2 +3 more | View in SCUBA |
About the gene
| Synonyms | KIAA0807, MAST205 |
|---|---|
| Chromosome | 1: 45786987-46036122 |
| Predicted location | Membrane |
| Essential gene | No |
| Protein class | Cancer-related genes, Enzymes, Predicted membrane proteins |
| Molecular function | Kinase, Serine/threonine-protein kinase, Transferase |
Function
Appears to link the dystrophin/utrophin network with microtubule filaments via the syntrophins. Phosphorylation of DMD or UTRN may modulate their affinities for associated proteins. Functions in a multi-protein complex in spermatid maturation. Regulates lipopolysaccharide-induced IL-12 synthesis in macrophages by forming a complex with TRAF6, resulting in the inhibition of TRAF6 NF-kappa-B activation (By similarity)
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.