Apicobasal polarity scaffold
Gene co-expression module in Enterocytes
| Category | Migration & adhesion |
|---|---|
| Genes | 12 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 6 of 12 genes have a known function matching the annotation |
Why this annotation
MAGI3, PATJ, NUMB, STK3 and MAST2 are apicobasal polarity and tight-junction scaffolds, and STK3 (MST2) is the Hippo pathway kinase. ADGRG7 and MGAM2 are absorptive enterocyte markers. RAPGEF5, TCF12, CAMK2D and DPYD are long genes consistent with a broadly expressed polarity program.
Genes
ADGRG7, CAMK2D, DPYD, MAGI3, MAST2, MGAM2, NUMB, PATJ, PRELID2, RAPGEF5, STK3, TCF12
Most correlated modules
- Apical junction complex · correlation 0.77
- Focal adhesion actin · correlation 0.71
- YAP cytoskeletal remodeling · correlation 0.67
- Colonocyte differentiation TFs · correlation 0.64
- Long-gene nuclear transcripts · correlation 0.60
- Mature colonocyte metabolism · correlation 0.53
- Serotonergic receptor signaling · correlation 0.47
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.