NUMB — NUMB endocytic adaptor protein
NUMB belongs to a gene co-expression module in 5 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
NUMB's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | Membrane trafficking Housekeeping | BCL2, CLSTN1, GLB1, GTF2I, HPSE, HSDL2, LENG8, MBIP +19 more | View in SCUBA |
| Enterocytes | Apicobasal polarity scaffold Migration & adhesion | ADGRG7, CAMK2D, DPYD, MAGI3, MAST2, MGAM2, PATJ, PRELID2 +3 more | View in SCUBA |
| Gamma-delta T cells | Immune Negative Regulation Immune regulation | ATAD1, CABIN1, DGLUCY, FYB1, GMIP, ICE2, KMT5B, NFX1 +4 more | |
| Macrophages | Monocyte Lipid Metabolism Lipid metabolism | ATP13A3, CEP170, CHIC2, COQ10B, CSGALNACT2, ENOSF1, HIPK2, HMGXB3 +14 more | View in SCUBA |
| Neutrophils | Endocytic Vesicle Trafficking Vesicular traficking | CPQ, PACSIN2, PLXDC2, PREX1, RBM47, SBF2, TBL1X, TECPR2 +1 more |
About the gene
| Synonyms | C14orf41 |
|---|---|
| Chromosome | 14: 73275107-73458617 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Cancer-related genes, Predicted intracellular proteins |
| Molecular function | Developmental protein |
| Biological process | Neurogenesis |
Function
Regulates clathrin-mediated receptor endocytosis. Plays a role in the process of neurogenesis (By similarity). Required throughout embryonic neurogenesis to maintain neural progenitor cells, also called radial glial cells (RGCs), by allowing their daughter cells to choose progenitor over neuronal cell fate (By similarity). Not required for the proliferation of neural progenitor cells before the onset of neurogenesis. Also involved postnatally in the subventricular zone (SVZ) neurogenesis by regulating SVZ neuroblasts survival and ependymal wall integrity (By similarity). May also mediate local repair of brain ventricular wall damage (By similarity).
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.