Brush Border Cytoskeleton
Gene co-expression module in Colonocytes
| Category | Cytoskeletal |
|---|---|
| Genes | 0 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 14 of 23 genes have a known function matching the annotation |
Why this annotation
TMIGD1 (17.5x sen_colono) is a brush border marker of mature colonocytes. ESPN encodes espin, an actin-bundling protein critical for microvillar structure. MEP1A is a brush border metalloprotease. SYNPO (synaptopodin) and MYLK (myosin light chain kinase) regulate apical actin/myosin. CLIP2 is a cytoplasmic linker, MAST2 a microtubule-associated kinase, TUBAL3 a tubulin isoform, and RHOU/PLEKHG6 are Rho GTPase signaling components. ACOX1 (peroxisomal FA oxidation), SULT1A2, and PHLPP2 add metabolic/signaling context. The dominant program is brush border cytoskeletal organization in mature colonocytes.
Genes
Most correlated modules
- Senescent Colonocyte Identity · correlation 0.92
- Colonocyte Water Transport · correlation 0.91
- Mature Colonocyte Identity · correlation 0.91
- ESCRT Membrane Remodeling · correlation 0.88
- Nuclear Receptor Signaling · correlation 0.81
- Lipid Xenobiotic Metabolism · correlation 0.78
- Colonocyte Solute Transport · correlation 0.77
- Cytoskeletal Remodeling · correlation 0.73
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.