Replication Origin Licensing
Gene co-expression module in Hematopoietic progenitor cells
| Category | Cell cycle |
|---|---|
| Genes | 9 |
| Annotation certainty | 5 of 5 |
| Annotation consistency | 9 of 9 genes have a known function matching the annotation |
Why this annotation
Hub genes CLSPN (claspin, replication fork/checkpoint), BRCA1 (DNA damage/HR repair), MCM10 (MCM helicase loading, replication initiation), CDC6 (replication licensing factor), XRCC2 (HR repair), ORC6 (origin recognition complex, replication licensing), DTL/CDT2 (CRL4 ubiquitin ligase, replication licensing control), FAM111B (replication fork), WDR76 (replication-associated). This module is focused on replication origin firing and licensing (ORC6, CDC6, MCM10, CDT1 pathway), with DNA damage checkpoint/repair overlay (BRCA1, CLSPN, XRCC2). Very low pct positive (2.2%) indicates rare, actively licensing cells — likely G1/S boundary. Neighbor to M66 (S-phase) confirms this is the earliest S-phase/replication initiation module.
Genes
BRCA1, CDC6, CLSPN, DTL, FAM111B, MCM10, ORC6, WDR76, XRCC2
Most correlated modules
- DNA Replication S-phase · correlation 0.94
- S-phase Progression · correlation 0.92
- Late S-phase G2 Entry · correlation 0.90
- Mitotic Spindle Checkpoint · correlation 0.86
- RNA Processing Housekeeping · correlation 0.72
- DNA Damage Repair · correlation 0.71
- Proteostasis & OxPhos · correlation 0.70
- Mitotic Spindle · correlation 0.70
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.