MPPE1 — Metallophosphoesterase 1
MPPE1 belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
MPPE1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Gamma-delta T cells | Transcriptional Repressor Complex DNA/chromatin regulation | BAG1, CAB39, CLEC2B, EBP, FBXO31, GFI1, MAN1A1, MAP2K1 +14 more | |
| Macrophages | Macrophage Identity Innate immunity | CCDC88B, CSF1R, CYP4V2, CYSLTR1, EVL, FAM53B, FOXRED2, GATM +15 more | View in SCUBA |
About the gene
| Synonyms | Cdc1, PGAP5 |
|---|---|
| Chromosome | 18: 11882622-11908366 |
| Predicted location | Intracellular, Membrane |
| Essential gene | No |
| Protein class | Predicted intracellular proteins, Predicted membrane proteins |
| Molecular function | Hydrolase |
| Biological process | ER-Golgi transport, GPI-anchor biosynthesis, Transport |
Function
Metallophosphoesterase that catalyzes the removal of a side- chain ethanolamine-phosphate (EtNP) from the second mannose of the GPI- anchor protein intermediate. Participates in the glycan remodeling steps of GPI-anchor maturation to allow an efficient transport of GPI-anchor proteins from the endoplasmic reticulum to the Golgi
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.