Transcriptional Repressor Complex
Gene co-expression module in Gamma-delta T cells
| Category | DNA/chromatin regulation |
|---|---|
| Genes | 23 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 6 of 23 genes have a known function matching the annotation |
Why this annotation
Hub PAXBP1 is a chromatin/transcriptional co-regulator. TBL1XR1 is part of the NCoR/SMRT transcriptional repressor complex. RB1 is a canonical cell cycle and transcriptional repressor. BAG1 is a co-chaperone with anti-apoptotic and transcriptional roles. STRN3 is a PP2A scaffolding component involved in signaling. MAN1A1 (glycosylation) and PANK2 (CoA synthesis) are metabolic. Overall the module is heterogeneous but the most coherent thread across top-ranked genes is transcriptional/chromatin regulation involving repressor complexes. Moderate coherence with many weak-membership genes dilutes the signal.
Genes
BAG1, CAB39, CLEC2B, EBP, FBXO31, GFI1, MAN1A1, MAP2K1, MFSD6, MPPE1, MTCH1, PANK2, PAXBP1, PFDN2, PHF5A, RB1, SLMAP, SMAD4, SPPL2A, STRN3, TBL1XR1, TMEM131, TUG1
Most correlated modules
- RNA Surveillance/NMD · correlation 0.90
- T Cell Migration · correlation 0.88
- RNA Binding/Splicing · correlation 0.85
- ER Protein Biogenesis · correlation 0.84
- Transcriptional Coactivation · correlation 0.79
- Pre-mRNA Splicing · correlation 0.79
- Chromatin Remodeling Signaling · correlation 0.79
- T Cell Phosphatase Signaling · correlation 0.78
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.