CCDC88B — Coiled-coil domain containing 88B
CCDC88B belongs to a gene co-expression module in 6 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
CCDC88B's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD19⁺ B cells | Lymphoid signaling regulators BCR/AP1/NFKb pathway | FGD2, IKZF1, LENG8, MACF1, OGT, PCSK7, PHYKPL, PNISR +4 more | View in SCUBA |
| CD4⁺ T cells | PD-L1 checkpoint Immune regulation | ADAM12, CASS4, CD274, GALNT10, HUWE1, INPP5D, KIF3B, LASP1 +13 more | View in SCUBA |
| Gamma-delta T cells | T Cell Migration migration & adhesion | BCL2, BPNT2, DNM2, EDC4, GMDS, LRRC58, MARK3, MDFIC +14 more | |
| Macrophages | Macrophage Identity Innate immunity | CSF1R, CYP4V2, CYSLTR1, EVL, FAM53B, FOXRED2, GATM, GPR155 +15 more | View in SCUBA |
| Monocytes | Myeloid Activation Innate immunity | GAS7, IL17RA, ITGAM, LTB4R, PRAM1, PSTPIP1, TMEM91 | View in SCUBA |
| Mucosal-associated invariant T cell | RNA Splicing Processing RNA processing & translation | EHBP1L1, EIF3A, GAB3, KDM5A, KIDINS220, LIX1L, PCSK7, SCAF11 +4 more |
About the gene
| Synonyms | BRLZ, CCDC88, FLJ00354, FLJ37970, GIPIE, HkRP3 |
|---|---|
| Chromosome | 11: 64340204-64357534 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins |
| Biological process | Stress response |
Function
Acts as a positive regulator of T-cell maturation and inflammatory function. Required for several functions of T-cells, in both the CD4(+) and the CD8(+) compartments and this includes expression of cell surface markers of activation, proliferation, and cytokine production in response to specific or non-specific stimulation (By similarity). Enhances NK cell cytotoxicity by positively regulating polarization of microtubule-organizing center (MTOC) to cytotoxic synapse, lytic granule transport along microtubules, and dynein- mediated clustering to MTOC. Interacts with HSPA5 and stabilizes the interaction between HSPA5 and ERN1, leading to suppression of ERN1-induced JNK activation and endoplasmic reticulum stress-induced apoptosis.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.