MYB — MYB proto-oncogene, transcription factor
MYB belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
MYB's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | Tfh IL21 help B cell help | APBB2, CDYL2, GDF7, HIF1A, IL21, KIAA1671, MFHAS1, PDCD1 +6 more | View in SCUBA |
| Hematopoietic progenitor cells | HSC Progenitor Proliferation Stemness | AMD1, CDK6, GNAQ, GSE1, RNF24, SPN, STAT5A, ZEB2 |
About the gene
| Synonyms | c-myb |
|---|---|
| Chromosome | 6: 135181308-135219173 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Cancer-related genes, Human disease related genes, Predicted intracellular proteins, Transcription factors |
| Molecular function | Activator, DNA-binding |
| Biological process | Transcription, Transcription regulation |
Function
Transcriptional activator; DNA-binding protein that specifically recognize the sequence 5'-YAAC[GT]G-3'. Plays an important role in the control of proliferation and differentiation of hematopoietic progenitor cells
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.