STAT5A — Signal transducer and activator of transcription 5A
STAT5A belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
STAT5A's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | NF-kB activation TCR/AP1/NFKb pathway | ABCF1, BCL2A1, BUD23, BZW2, CALR, CEBPZ, DDX21, DENND4A +21 more | View in SCUBA |
| Gamma-delta T cells | TCR Signal Regulation TCR Signaling | ADORA2A, ANO9, CAMK4, CASK, CCR5, CD84, CDC14A, CXCR6 +22 more | |
| Hematopoietic progenitor cells | HSC Progenitor Proliferation Stemness | AMD1, CDK6, GNAQ, GSE1, MYB, RNF24, SPN, ZEB2 | |
| Lymphatic endothelial | NF-κB Inflammatory Activation Inflammation | ACHE, ANKLE2, CD200, CXCL1, CXCL8, HMGA1, ICOSLG, NFKB2 +9 more | View in SCUBA |
About the gene
| Synonyms | MGF, STAT5 |
|---|---|
| Chromosome | 17: 42287547-42311943 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Cancer-related genes, Plasma proteins, Predicted intracellular proteins, Transcription factors |
| Molecular function | Activator, DNA-binding |
| Biological process | Lactation, Transcription, Transcription regulation |
Function
Carries out a dual signal transduction and activation of transcription. Mediates cellular responses to the cytokine KITLG/SCF and other growth factors. Mediates cellular responses to ERBB4. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. Binds to the GAS element and activates PRL- induced transcription. Regulates the expression of milk proteins during lactation
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.