HSC Progenitor Proliferation
Gene co-expression module in Hematopoietic progenitor cells
| Category | Stemness |
|---|---|
| Genes | 9 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 7 of 9 genes have a known function matching the annotation |
Why this annotation
MYB is a critical transcription factor for HSC maintenance and progenitor proliferation. STAT5A is downstream of cytokine receptors (EPO, SCF, IL-2) central to hematopoietic progenitor survival and proliferation. CDK6 drives G1 progression and is uniquely important for HSC quiescence exit and lymphoid/myeloid development. ZEB2 is a TF involved in myeloid and NK cell differentiation. SPN (CD43) marks hematopoietic stem and progenitor cells and myeloid cells. GNAQ mediates G-protein signaling in hematopoietic cells. AMD1 (adenosylmethionine decarboxylase) supports polyamine synthesis for proliferating progenitors. This module defines an HSC/multipotent progenitor proliferation state.
Genes
AMD1, CDK6, GNAQ, GSE1, MYB, RNF24, SPN, STAT5A, ZEB2
Most correlated modules
- Erythroid Progenitor Program · correlation 0.88
- Erythro-Megakaryocytic Development · correlation 0.87
- Chromatin Remodeling · correlation 0.83
- Replication Stress Response · correlation 0.82
- General Metabolic Housekeeping · correlation 0.79
- Hematopoietic Progenitor Identity · correlation 0.78
- Oxidative Stress Survival · correlation 0.78
- Biosynthetic Housekeeping · correlation 0.75
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.