NCKAP1 — NCK associated protein 1
NCKAP1 belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
NCKAP1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | WAVE Complex Cytoskeleton Cytoskeletal | ATP2B4, C6orf89, CD46, CYFIP1, DYNC1LI2, GIT1, GNB1, IQGAP1 +3 more | View in SCUBA |
| Smooth muscle cells | Generic maintenance transcripts Housekeeping | CHMP2A, EMP3, HMGN1, MRPL57, PAIP2, PSMB2, SLC25A5, TAX1BP3 +5 more | View in SCUBA |
About the gene
| Synonyms | HEM2, Nap1, NAP125 |
|---|---|
| Chromosome | 2: 182909115-183038858 |
| Predicted location | Membrane |
| Essential gene | No |
| Protein class | Predicted membrane proteins |
| Biological process | Host-virus interaction |
Function
Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex. Actin remodeling activity is regulated by RAC1. As component of the WAVE1 complex, required for BDNF-NTRK2 endocytic trafficking and signaling from early endosomes
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.