TAX1BP3 — Tax1 binding protein 3
TAX1BP3 belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
TAX1BP3's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Glial cells | Peripheral Glial Myelination Myelination | FAM210B, FRMD6, GNAS, KDSR, MAF, MYL9, OLFML2A, OLFML3 +7 more | View in SCUBA |
| Smooth muscle cells | Generic maintenance transcripts Housekeeping | CHMP2A, EMP3, HMGN1, MRPL57, NCKAP1, PAIP2, PSMB2, SLC25A5 +5 more | View in SCUBA |
About the gene
| Synonyms | TIP-1 |
|---|---|
| Chromosome | 17: 3662895-3668679 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins |
| Biological process | Wnt signaling pathway |
Function
May regulate a number of protein-protein interactions by competing for PDZ domain binding sites. Binds CTNNB1 and may thereby act as an inhibitor of the Wnt signaling pathway. Competes with LIN7A for KCNJ4 binding, and thereby promotes KCNJ4 internalization. May play a role in the Rho signaling pathway. May play a role in activation of CDC42 by the viral protein HPV16 E6.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.