WAVE Complex Cytoskeleton
Gene co-expression module in Endothelial
| Category | Cytoskeletal |
|---|---|
| Genes | 12 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 8 of 12 genes have a known function matching the annotation |
Why this annotation
Hub genes NCKAP1 and CYFIP1 are core WAVE regulatory complex members driving Arp2/3-mediated actin polymerization. DYNC1LI2 is a dynein light intermediate chain (microtubule motor), MAP7D1 is a microtubule-associated protein, IQGAP1 is a cytoskeletal scaffold linking actin and microtubules, GIT1 is a GTPase-interacting protein regulating focal adhesion/actin dynamics, TMEM30A is a phospholipid flippase subunit, and TGOLN2 marks trans-Golgi vesicle trafficking. GNB1 (G-protein beta) and CD46 (complement regulator) are peripheral members. The module reflects actin/microtubule cytoskeletal organization and vesicle trafficking, mildly upregulated in IBD inflammation consistent with endothelial cytoskeletal remodeling.
Genes
ATP2B4, C6orf89, CD46, CYFIP1, DYNC1LI2, GIT1, GNB1, IQGAP1, MAP7D1, NCKAP1, TGOLN2, TMEM30A
Most correlated modules
- Chromatin Cell Cycle · correlation 0.92
- Integrin-Actin Adhesion · correlation 0.90
- Endothelial Angiogenic Identity · correlation 0.90
- Cytoskeletal Scaffolding · correlation 0.90
- Endocytic Membrane Remodeling · correlation 0.88
- Endothelial Junction Identity · correlation 0.87
- Hippo-YAP Cytoskeletal · correlation 0.85
- Inflammatory Angiogenic Activation · correlation 0.83
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.