Generic maintenance transcripts
Gene co-expression module in Smooth muscle cells
| Category | Housekeeping |
|---|---|
| Genes | 14 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 11 of 14 genes have a known function matching the annotation |
Why this annotation
No dominant pathway: a grab-bag of ubiquitously expressed maintenance genes spanning proteasome (PSMB2), chromatin (HMGN1), mitochondrial transport/respiration (SLC25A5, MRPL57, UQCRC1), vesicle trafficking (TMED2, CHMP2A), translation control (PAIP2) and actin regulation (NCKAP1). Moderate coherence with mostly moderate/weak memberships and uniform, low detection is typical of a broadly co-varying housekeeping/ambient-depth module rather than a defined biological program. Its neighbors (M110, M123, M55) are similarly generic maintenance modules, supporting a shared library-size/basal-metabolism driver.
Genes
CHMP2A, EMP3, HMGN1, MRPL57, NCKAP1, PAIP2, PSMB2, SLC25A5, TAX1BP3, TM2D1, TMED2, TWSG1, UQCRC1, YPEL5
Most correlated modules
- Post-translational regulators · correlation 0.89
- Lysosomal-secretory processing · correlation 0.88
- Ribonucleoprotein & translation · correlation 0.86
- OxPhos & proteasome · correlation 0.86
- Costameric cytoskeleton · correlation 0.85
- Actin remodeling · correlation 0.84
- SMC Phenotype Regulation · correlation 0.83
- Adhesion Activation · correlation 0.75
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.