NCS1 — Neuronal calcium sensor 1
NCS1 belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
NCS1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Fibroblasts | ICC electrophysiological machinery Gut motility | ADRB3, CAP2, CDCA7L, CSRP2, DTNA, GREM2, LGI1, LMO3 +5 more | View in SCUBA |
| Smooth muscle cells | SMC Ion Signaling Contractility | ANTXR2, ATP1B1, CDKN1C, CENPW, FAM83D, FXYD6, GAS1, KCNMA1 +12 more | View in SCUBA |
About the gene
| Synonyms | FREQ, NCS-1 |
|---|---|
| Chromosome | 9: 130172404-130237303 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins |
Function
Neuronal calcium sensor, regulator of G protein-coupled receptor phosphorylation in a calcium dependent manner. Directly regulates GRK1 (RHOK), but not GRK2 to GRK5. Can substitute for calmodulin (By similarity). Stimulates PI4KB kinase activity (By similarity). Involved in long-term synaptic plasticity through its interaction with PICK1 (By similarity). May also play a role in neuron differentiation through inhibition of the activity of N-type voltage- gated calcium channel (By similarity)
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.