SMC Ion Signaling
Gene co-expression module in Smooth muscle cells
| Category | Contractility |
|---|---|
| Genes | 21 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 7 of 21 genes have a known function matching the annotation |
Why this annotation
A mixed but mesenchymally coherent module combining excitation/ion-handling genes of differentiated visceral smooth muscle (KCNMA1 BK channel, ATP1B1 Na/K-ATPase subunit, FXYD6 ion-pump regulator, PCP4 calmodulin-binding Purkinje protein, NCS1 calcium sensor, RAMP1 CGRP receptor component, MACF1 cytoskeletal crosslinker) with developmental/growth-restraining regulators (GAS1, LRIG1, MEIS2, NRP2, SPOCK1, ANTXR2). The combination suggests a differentiated, quiescent SMC state with calcium/ion-signalling machinery; FAM83D and CENPW are minor proliferation-linked passengers that likely drive the edges to the neighboring cell-cycle modules. Moderate/weak membership of several hubs indicates two entangled sub-programs.
Genes
ANTXR2, ATP1B1, CDKN1C, CENPW, FAM83D, FXYD6, GAS1, KCNMA1, LRIG1, MACF1, MEIS2, NCS1, NRP2, PCP4, PIK3R1, PSD, RAMP1, SGMS2, SPIN1, SPOCK1, TCEAL2
Most correlated modules
- Microfibrillar ECM Program · correlation 0.71
- Contractile SMC phenotype · correlation 0.67
- BMP-antagonist Niche · correlation 0.62
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.