FXYD6 — FXYD domain containing ion transport regulator 6
FXYD6 belongs to a gene co-expression module in 5 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
FXYD6's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | EC Cytoskeletal Scaffold Cytoskeletal | ADD3, ANTXR2, CTSD, EPB41L2, GYPC, MAP4K2, NRP2, RECK +2 more | View in SCUBA |
| Fibroblasts | Quiescent Anti-inflammatory Fibroblast Developmental | ADIRF, CHCHD10, DACH1, IGFBP3, KHDRBS3, LSP1, NDRG2, PDE1A +3 more | View in SCUBA |
| Glial cells | Enteric Glial Homeostasis Housekeeping | APOE, BCHE, CCND3, COL12A1, ENTPD2, NPDC1, PAQR6, PCSK1N +5 more | View in SCUBA |
| Lymphatic endothelial | Oxidative Stress Protection Stress | ALDH2, ANAPC16, BCL7C, CAVIN2, CCL21, CD320, CRACR2B, GUSB +10 more | View in SCUBA |
| Smooth muscle cells | SMC Ion Signaling Contractility | ANTXR2, ATP1B1, CDKN1C, CENPW, FAM83D, GAS1, KCNMA1, LRIG1 +12 more | View in SCUBA |
About the gene
| Chromosome | 11: 117836976-117877486 |
|---|---|
| Predicted location | Membrane |
| Essential gene | No |
| Protein class | Predicted membrane proteins, Transporters |
| Biological process | Ion transport, Potassium transport, Sodium transport, Sodium/potassium transport, Transport |
Function
Associates with and regulates the activity of the sodium/potassium-transporting ATPase (NKA) which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Reduces the apparent affinity for intracellular Na(+) with no change in the apparent affinity for extracellular K(+). In addition to modulating NKA kinetics, may also function as a regulator of NKA localization to the plasma membrane (By similarity).
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.