ANTXR2 — ANTXR cell adhesion molecule 2
ANTXR2 belongs to a gene co-expression module in 5 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
ANTXR2's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD19⁺ B cells | B-cell Maturation B cell maturation | ANK3, CD24, COL4A3, COL4A4, CSGALNACT1, ITM2C, PDCD4, PPP1R2C +3 more | View in SCUBA |
| Endothelial | EC Cytoskeletal Scaffold Cytoskeletal | ADD3, CTSD, EPB41L2, FXYD6, GYPC, MAP4K2, NRP2, RECK +2 more | View in SCUBA |
| Gamma-delta T cells | Lymphocyte Tissue Egress migration & adhesion | ADRB2, C1orf162, KLRG1, NSG1, RASSF3, RIPOR2, S1PR1, SAMD3 +7 more | |
| Glial cells | Basement Membrane Adhesion ECM remodeling | C2orf88, CHL1, DMD, GPC1, ITGAV, PRIMA1, TMEM123 | View in SCUBA |
| Smooth muscle cells | SMC Ion Signaling Contractility | ATP1B1, CDKN1C, CENPW, FAM83D, FXYD6, GAS1, KCNMA1, LRIG1 +12 more | View in SCUBA |
About the gene
| Synonyms | CMG-2, CMG2, FLJ31074 |
|---|---|
| Chromosome | 4: 79901146-80125454 |
| Predicted location | Intracellular, Membrane |
| Essential gene | No |
| Protein class | Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins |
| Molecular function | Receptor |
Function
Necessary for cellular interactions with laminin and the extracellular matrix. (Microbial infection) Receptor for the protective antigen (PA) of B.anthracis. Binding of PA leads to heptamerization of the receptor-PA complex. Upon binding of the PA of B.anthracis, the complex moves to glycosphingolipid-rich lipid rafts, where it is internalized via a clathrin-dependent pathway. In the endosomal membrane, at pH under 7, the complex then rearranges and forms a pore allowing the other components of anthrax toxin to escape to the cytoplasm.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.