NLRP12 — NLR family pyrin domain containing 12
NLRP12 belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
NLRP12's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Monocytes | p38 MAPK Signaling Inflammatory | CREB5, CRISPLD2, FBXL5, LBR, LRRK2, MAPK14, MEGF9, NFE2 +5 more | View in SCUBA |
| Neutrophils | Inflammasome Signaling Regulation Inflammatory | ADAM19, F5, MAP2K6, PRKACA, RNF10, SLC37A3, TENM1 |
About the gene
| Synonyms | CLR19.3, Monarch1, NALP12, PAN6, PYPAF7, RNO2 |
|---|---|
| Chromosome | 19: 53793741-53824403 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Disease related genes, Human disease related genes, Predicted intracellular proteins |
Function
Plays an essential role as an potent mitigator of inflammation. Primarily expressed in dendritic cells and macrophages, inhibits both canonical and non-canonical NF-kappa-B and ERK activation pathways. Functions as a negative regulator of NOD2 by targeting it to degradation via the proteasome pathway. In turn, promotes bacterial tolerance. Also inhibits the RIGI- mediated immune signaling against RNA viruses by reducing the E3 ubiquitin ligase TRIM25-mediated 'Lys-63'-linked RIGI activation but enhancing the E3 ubiquitin ligase RNF125-mediated 'Lys-48'-linked RIGI degradation. Also acts as a negative regulator of inflammatory response to mitigate obesity and obesity-associated diseases in adipose tissue (By similarity).
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.