TENM1 — Teneurin transmembrane protein 1

TENM1 belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

TENM1's module in each cell type

Cell type	Module	Shares the module with
Monocytes	BPI Antibacterial Response Antibacterial	ADGRG3, ANXA3, BPI, CMTM2, CST7, CYP4F3, LGALS12, MGAM +6 more	View in SCUBA
Neutrophils	Inflammasome Signaling Regulation Inflammatory	ADAM19, F5, MAP2K6, NLRP12, PRKACA, RNF10, SLC37A3

About the gene

Synonyms	ODZ1, ODZ3, TEN-M1, TEN1, TNM
Chromosome	X: 124375903-125204312
Predicted location	Membrane
Essential gene	No
Protein class	Predicted membrane proteins, Transporters
Molecular function	Neuropeptide, Repressor
Biological process	Stress response, Transcription, Transcription regulation

Function

Involved in neural development, regulating the establishment of proper connectivity within the nervous system. May function as a cellular signal transducer (By similarity). Plays a role in the regulation of neuroplasticity in the limbic system. Mediates a rapid reorganization of actin- and tubulin-based cytoskeleton elements with an increase in dendritic arborization and spine density formation of neurons in the hippocampus and amygdala. Induces BDNF transcription inhibition in neurons. Activates the mitogen-activated protein (MAP) kinase 2 (MEK2) and extracellular signal-regulated kinase (ERK) cascade. Also acts as a bioactive neuroprotective peptide on limbic neurons of the brain and regulates stress-induced behavior: attenuates alkalosis-associated necrotic cell death and the effects of corticotropin-releasing factor (CRF) on c-fos/FOS induction and on the reinstatement of cocaine seeking (By similarity). Induces gene transcription activation

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.