NOTCH4 — Notch receptor 4
NOTCH4 belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
NOTCH4's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | Venous Endothelial Identity Endothelial cell development | ACE, ADARB1, CDC42EP1, CLSTN1, EMCN, FLT1, GALNT18, GPRC5B +11 more | View in SCUBA |
| Pericytes | Vascular Pericyte Identity Developmental | ABCG1, ACVRL1, ATP11A, CASP10, CCM2L, CD320, GPRC5B, KL +7 more | View in SCUBA |
About the gene
| Synonyms | INT3 |
|---|---|
| Chromosome | 6: 32194843-32224067 |
| Predicted location | Membrane |
| Essential gene | No |
| Protein class | Human disease related genes, Predicted membrane proteins |
| Molecular function | Activator, Developmental protein, Receptor |
| Biological process | Differentiation, Host-virus interaction, Notch signaling pathway, Transcription, Transcription regulation |
Function
Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. May regulate branching morphogenesis in the developing vascular system (By similarity)
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.