ABCG1 — ATP binding cassette subfamily G member 1
ABCG1 belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
ABCG1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Enterocytes | Brush border lipid handling Absorption | ABHD12, ARL14, CDHR2, ENTPD8, IDS, PNPLA2, RAI14, SEMA3G +2 more | View in SCUBA |
| Pericytes | Vascular Pericyte Identity Developmental | ACVRL1, ATP11A, CASP10, CCM2L, CD320, GPRC5B, KL, MPZL2 +7 more | View in SCUBA |
About the gene
| Synonyms | ABC8 |
|---|---|
| Chromosome | 21: 42199689-42297244 |
| Predicted location | Intracellular, Membrane |
| Essential gene | No |
| Protein class | Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins, Transporters |
| Molecular function | Translocase |
| Biological process | Lipid transport, Transport |
Function
Catalyzes the efflux of phospholipids such as sphingomyelin, cholesterol and its oxygenated derivatives like 7beta- hydroxycholesterol and this transport is coupled to hydrolysis of ATP. The lipid efflux is ALB-dependent. Is an active component of the macrophage lipid export complex. Could also be involved in intracellular lipid transport processes. The role in cellular lipid homeostasis may not be limited to macrophages. Prevents cell death by transporting cytotoxic 7beta- hydroxycholesterol.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.