Vascular Pericyte Identity
Gene co-expression module in Pericytes
| Category | Developmental |
|---|---|
| Genes | 16 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 10 of 16 genes have a known function matching the annotation |
Why this annotation
Hub genes ACVRL1 (ALK1), TGFBR2, NOTCH4, CCM2L, and SCARF1 define a vascular pericyte identity program centered on TGF-β/BMP and Notch signaling pathways critical for arteriovenous specification and vascular homeostasis. KL (Klotho) and ATP11A add anti-aging/lipid asymmetry components. The module is significantly downregulated in UC and CD inflammation and recovers in remission, consistent with loss of homeostatic pericyte identity during IBD. Neighbor modules M62 and M50 share vascular receptor themes, reinforcing this as part of a broader vascular homeostasis neighborhood.
Genes
ABCG1, ACVRL1, ATP11A, CASP10, CCM2L, CD320, GPRC5B, KL, MPZL2, NOTCH4, PITPNC1, SCARF1, SEC14L1, STXBP1, TGFBR2, TNFRSF4
Most correlated modules
- Pericyte Contractile Tone · correlation 0.99
- Vascular Permeability · correlation 0.99
- MHC-II Antigen Presentation · correlation 0.98
- Rho GTPase Signaling · correlation 0.98
- Angiogenic Receptor Signaling · correlation 0.97
- Vascular Junction Adhesion · correlation 0.96
- BMP-SMAD Signaling · correlation 0.96
- G1 Cell Cycle Entry · correlation 0.95
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.