KL — Klotho
KL belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
KL's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | IL-27 Receptor Signaling Inflammation | CCND3, CDC37, HOXB2, IL27RA, MMP15, NDUFA12, SPARCL1, TMEM243 | View in SCUBA |
| Pericytes | Vascular Pericyte Identity Developmental | ABCG1, ACVRL1, ATP11A, CASP10, CCM2L, CD320, GPRC5B, MPZL2 +7 more | View in SCUBA |
About the gene
| Synonyms | KLA |
|---|---|
| Chromosome | 13: 33016423-33066143 |
| Predicted location | Membrane, Secreted |
| Essential gene | No |
| Protein class | Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted membrane proteins, Predicted secreted proteins, Transporters |
| Molecular function | Glycosidase, Hormone, Hydrolase |
Function
May have weak glycosidase activity towards glucuronylated steroids. However, it lacks essential active site Glu residues at positions 239 and 872, suggesting it may be inactive as a glycosidase in vivo. May be involved in the regulation of calcium and phosphorus homeostasis by inhibiting the synthesis of active vitamin D (By similarity). Essential factor for the specific interaction between FGF23 and FGFR1 (By similarity). The Klotho peptide generated by cleavage of the membrane- bound isoform may be an anti-aging circulating hormone which would extend life span by inhibiting insulin/IGF1 signaling
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.