OLFM2 — Olfactomedin 2
OLFM2 belongs to a gene co-expression module in 1 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
OLFM2's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Pericytes | Pericyte ECM Secretion ECM production | ATP1A2, CPM, CSRP2, DACH1, EFEMP1, FRZB, GULP1, MASP1 +3 more | View in SCUBA |
About the gene
| Synonyms | NOE2, OlfC |
|---|---|
| Chromosome | 19: 9853718-9936515 |
| Predicted location | Intracellular, Secreted |
| Essential gene | No |
| Protein class | Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins |
Function
Involved in transforming growth factor beta (TGF-beta)- induced smooth muscle differentiation. TGF-beta induces expression and translocation of OLFM2 to the nucleus where it binds to SRF, causing its dissociation from the transcriptional repressor HEY2/HERP1 and facilitating binding of SRF to target genes. Plays a role in AMPAR complex organization (By similarity). Is a regulator of vascular smooth-muscle cell (SMC) phenotypic switching, that acts by promoting RUNX2 and inhibiting MYOCD binding to SRF. SMC phenotypic switching is the process through which vascular SMCs undergo transition between a quiescent contractile phenotype and a proliferative synthetic phenotype in response to pathological stimuli. SMC phenotypic plasticity is essential for vascular development and remodeling (By similarity).
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.