OLFM4 — Olfactomedin 4
OLFM4 belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
OLFM4's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Goblet cells | Mucosal Innate Defense Immune function | BOLA3, CTSS, DMBT1, ENO1, GPI, LGALS3BP, PIGR, PLA2G2A +4 more | View in SCUBA |
| Neutrophils | Immature Neutrophil Granule Developmental | BPI, CCDC85B, CD24, CEACAM8, CPNE3, RETN, RGCC, SVIP |
About the gene
| Synonyms | GC1, GW112, OlfD |
|---|---|
| Chromosome | 13: 53028813-53052057 |
| Predicted location | Secreted |
| Essential gene | No |
| Protein class | Predicted secreted proteins |
| Biological process | Cell adhesion |
Function
May promote proliferation of pancreatic cancer cells by favoring the transition from the S to G2/M phase. In myeloid leukemic cell lines, inhibits cell growth and induces cell differentiation and apoptosis. May play a role in the inhibition of EIF4EBP1 phosphorylation/deactivation. Facilitates cell adhesion, most probably through interaction with cell surface lectins and cadherin.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.