GPI — Glucose-6-phosphate isomerase
GPI belongs to a gene co-expression module in 6 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
GPI's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | Membrane Trafficking Protein processing & ER | B4GALT1, BTF3L4, CELF1, CLTC, CSNK1G3, CTBS, DERL2, DYNC1LI2 +23 more | View in SCUBA |
| Enterocytes | Mitochondrial Energy Metabolism Mitochondrial & OxPhos | ALDH1A1, ALDH3A2, CPS1, GALM, GCNT1, GSTM4, MTCH2, NDUFV1 +2 more | View in SCUBA |
| Gamma-delta T cells | Metabolic-Translational Coupling RNA processing & translation | APOL6, ARCN1, ARGLU1, DCAF12, DDX23, EIF2S1, EIF4G1, FHOD1 +20 more | |
| Goblet cells | Mucosal Innate Defense Immune function | BOLA3, CTSS, DMBT1, ENO1, LGALS3BP, OLFM4, PIGR, PLA2G2A +4 more | View in SCUBA |
| Innate lymphoid cells | Cellular Metabolic Maintenance Metabolism | ADIPOR1, APH1A, ARF5, BCAP31, CLIC1, CSNK2B, CYB5R3, DHPS +13 more | View in SCUBA |
| Macrophages | Central Carbon Metabolism Housekeeping | ACLY, ACO2, CBFB, CSK, DARS1, DLD, DPAGT1, EMC1 +19 more | View in SCUBA |
About the gene
| Synonyms | AMF, NLK |
|---|---|
| Chromosome | 19: 34359480-34402413 |
| Predicted location | Intracellular, Membrane, Secreted |
| Essential gene | No |
| Protein class | Cancer-related genes, Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins, Predicted secreted proteins |
| Molecular function | Cytokine, Growth factor, Isomerase |
| Biological process | Gluconeogenesis, Glycolysis |
Function
In the cytoplasm, catalyzes the conversion of glucose-6- phosphate to fructose-6-phosphate, the second step in glycolysis, and the reverse reaction during gluconeogenesis. Besides it's role as a glycolytic enzyme, also acts as a secreted cytokine: acts as an angiogenic factor (AMF) that stimulates endothelial cell motility. Acts as a neurotrophic factor, neuroleukin, for spinal and sensory neurons. It is secreted by lectin-stimulated T-cells and induces immunoglobulin secretion.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.