PIGR — Polymeric immunoglobulin receptor
PIGR belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
PIGR's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Enterocytes | Actin cytoskeleton Cytoskeletal | ACTB, ACTG1, CAST, CDC42EP5, CLDN7, JPT1, MYL12B, TMEM54 | View in SCUBA |
| Goblet cells | Mucosal Innate Defense Immune function | BOLA3, CTSS, DMBT1, ENO1, GPI, LGALS3BP, OLFM4, PLA2G2A +4 more | View in SCUBA |
About the gene
| Chromosome | 1: 206928522-206946466 |
|---|---|
| Predicted location | Membrane, Secreted |
| Essential gene | No |
| Protein class | Cancer-related genes, Plasma proteins, Predicted membrane proteins, Predicted secreted proteins, Transporters |
Function
Mediates selective transcytosis of polymeric IgA and IgM across mucosal epithelial cells. Binds polymeric IgA and IgM at the basolateral surface of epithelial cells. The complex is then transported across the cell to be secreted at the apical surface. During this process, a cleavage occurs that separates the extracellular (known as the secretory component) from the transmembrane segment. Through its N-linked glycans ensures anchoring of secretory IgA (sIgA) molecules to mucus lining the epithelial surface to neutralize extracellular pathogens. On its own (free form) may act as a non-specific microbial scavenger to prevent pathogen interaction with epithelial cells.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.