Inflammatory Regenerative State
Gene co-expression module in Colonocytes
| Category | Inflammation |
|---|---|
| Genes | 0 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 14 of 31 genes have a known function matching the annotation |
Why this annotation
Hub genes CD82 (tetraspanin, suppresses metastasis/modulates signaling), CD44 (inflammation/stemness marker, strongly inf_colono), OLFM4 (intestinal stem cell/regenerative marker, 8.5x inf_colono), FXYD5 (dysadherin, pro-inflammatory, 5.8x inf_colono), SYTL1 (synaptotagmin-like vesicle trafficking, 4.3x inf_colono), FUT8 (core fucosylation), KCNE3 (potassium channel, epithelial ion transport), MIF (macrophage migration inhibitory factor/cytokine), NUCB2 (calcium-binding/secretory), PLS3 (plastin-3/actin bundling), and HDAC7 (epigenetic regulation) define an inflammatory colonocyte state with regenerative/stem-like features. Significantly upregulated in UC inflammation. OLFM4 and CD44 co-expression marks a regenerative inflammatory colonocyte state described in IBD.
Genes
Most correlated modules
- ER Glycoprotein Folding · correlation 0.81
- ER-Golgi Trafficking · correlation 0.81
- Inflammasome Activation · correlation 0.79
- Inflammatory Stress Response · correlation 0.78
- Secretory Differentiation · correlation 0.77
- Wound Regenerative Response · correlation 0.64
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.