P2RY6 — Pyrimidinergic receptor P2Y6
P2RY6 belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
P2RY6's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | Inflammatory EC Activation Inflammation | FJX1, FNDC3B, GPR4, HK1, ITGA5, MAP1S, MCAM, MSN +3 more | View in SCUBA |
| Macrophages | Efferocytosis Anti-inflammatory Lysosomal & pahgocytosis | ABHD12, ADGRG5, AIG1, AXL, CCS, CD101, CD1D, CD300A +18 more | View in SCUBA |
About the gene
| Synonyms | P2Y6 |
|---|---|
| Chromosome | 11: 73264498-73305103 |
| Predicted location | Membrane |
| Essential gene | No |
| Protein class | G-protein coupled receptors, Predicted membrane proteins |
| Molecular function | G-protein coupled receptor, Receptor, Transducer |
Function
Receptor for extracellular UDP > UTP > ATP. The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.