Inflammatory EC Activation
Gene co-expression module in Endothelial
| Category | Inflammation |
|---|---|
| Genes | 12 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 8 of 12 genes have a known function matching the annotation |
Why this annotation
Hub gene GPR4 is a proton-sensing GPCR that detects acidic pH in inflamed tissue and activates endothelial inflammatory responses. MCAM (CD146) marks activated endothelium. MSN (moesin), ITGA5, and VASP support cytoskeletal reorganization and integrin-mediated adhesion. SEMA3F provides vascular guidance context. P2RY6 is a purinergic receptor activated by inflammatory signals. HK1 links to metabolic reprogramming. The strong upregulation in UC and CD inflammation with reversal in remission supports an inflammatory vascular activation program centered on pH/purinergic sensing.
Genes
FJX1, FNDC3B, GPR4, HK1, ITGA5, MAP1S, MCAM, MSN, P2RY6, PLEKHA1, SEMA3F, VASP
Most correlated modules
- ECM Fibrotic Remodeling · correlation 0.89
- Basement Membrane Assembly · correlation 0.85
- Vascular Barrier Integrity · correlation 0.84
- UPR / ER Stress · correlation 0.83
- Actomyosin Contractility · correlation 0.83
- Inflammatory Lipid Metabolism · correlation 0.82
- VEGF Tip Cell Signaling · correlation 0.79
- Inflammatory Kinase Signaling · correlation 0.77
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.