CD300A — CD300a molecule
CD300A belongs to a gene co-expression module in 5 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
CD300A's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | Resting memory T cell Immune regulation | ANXA1, CDC14A, CYB561, DHRS3, DYNLT3, IL7R, MYADM, NECTIN3 +5 more | View in SCUBA |
| Gamma-delta T cells | TCR Proximal Signaling TCR Signaling | ADGRG5, BIN2, C11orf21, C12orf75, FGR, GPSM3, LAT, MATK +11 more | |
| Macrophages | Efferocytosis Anti-inflammatory Lysosomal & pahgocytosis | ABHD12, ADGRG5, AIG1, AXL, CCS, CD101, CD1D, EVA1B +18 more | View in SCUBA |
| Monocytes | Non-classical Monocyte Lysosomal & pahgocytosis | ABI3, CAMK1, CHCHD10, DAPK1, FCGR3A, GNGT2, ICAM2, ITM2B +5 more | View in SCUBA |
| Natural Killer cells | NK Cell Activation activation | AHNAK, AKT3, ANXA1, C16orf54, C1orf162, CD226, ITGAX, PLAC8 +2 more | View in SCUBA |
About the gene
| Synonyms | CMRF-35-H9, CMRF35H, IGSF12, IRC1, IRC2, Irp60 |
|---|---|
| Chromosome | 17: 74466399-74484794 |
| Predicted location | Intracellular, Membrane |
| Essential gene | No |
| Protein class | CD markers, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins |
| Molecular function | Receptor |
| Biological process | Cell adhesion, Immunity |
Function
Inhibitory receptor which may contribute to the down- regulation of cytolytic activity in natural killer (NK) cells, and to the down-regulation of mast cell degranulation. Negatively regulates the Toll-like receptor (TLR) signaling mediated by MYD88 but not TRIF through activation of PTPN6.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.