Efferocytosis Anti-inflammatory
Gene co-expression module in Macrophages
| Category | Lysosomal & pahgocytosis |
|---|---|
| Genes | 27 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 9 of 27 genes have a known function matching the annotation |
Why this annotation
CD1D (lipid antigen presentation to NKT cells), AXL (TAM receptor tyrosine kinase mediating efferocytosis and anti-inflammatory signaling), CD300A (inhibitory receptor on myeloid cells), IRF8 (master transcription factor for macrophage/DC differentiation), MS4A6A (macrophage marker), ITGB7 (gut-homing integrin), P2RY6 (purinergic receptor on macrophages), ABHD12 (lipid hydrolase). This module reflects macrophage identity with efferocytosis and anti-inflammatory receptor signaling, consistent with gut-resident macrophage homeostatic program.
Genes
ABHD12, ADGRG5, AIG1, AXL, CCS, CD101, CD1D, CD300A, EVA1B, GPATCH11, GPR160, GPR82, HACD4, HCAR2, IRF8, ITGB7, MS4A6A, MXD4, NME3, P2RY6, PXDC1, RB1, RGS18, SCN4B, SNAP29, SSBP4, TSPAN33
Most correlated modules
- Macrophage Proliferation · correlation 0.91
- Resident Mac Niche · correlation 0.85
- Macrophage Identity · correlation 0.84
- Stress Response Transcription · correlation 0.82
- Inflammasome Oxidative Stress · correlation 0.76
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.