PCID2 — PCI domain containing 2
PCID2 belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
PCID2's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Gamma-delta T cells | Actin-based Motility Cytoskeletal | APBB1IP, CD58, COMMD7, CORO1B, CTSD, EVL, FDFT1, HMOX2 +13 more | |
| Innate lymphoid cells | ILC1 Actin Motility Cytoskeleton & motility | ACAP1, ARHGDIB, CORO1A, DGCR6L, EVL, GPSM3, HEXA, LCK +14 more | View in SCUBA |
About the gene
| Synonyms | FLJ11305 |
|---|---|
| Chromosome | 13: 113177536-113208715 |
| Predicted location | Intracellular |
| Essential gene | Yes |
| Protein class | Essential proteins, Predicted intracellular proteins |
| Biological process | mRNA transport, Protein transport, Translocation, Transport |
Function
Required for B-cell survival through the regulation of the expression of cell-cycle checkpoint MAD2L1 protein during B cell differentiation (By similarity). As a component of the TREX-2 complex, involved in the export of mRNAs to the cytoplasm through the nuclear pores. Binds and stabilizes BRCA2 and is thus involved in the control of R-loop-associated DNA damage and transcription-associated genomic instability. Blocks the activity of the SRCAP chromatin remodeling complex by interacting with SRCAP complex member ZNHIT1 and inhibiting its interaction with the complex (By similarity). This prevents the deposition of histone variant H2AZ1/H2A.Z at the nucleosomes of key lymphoid fate regulator genes which suppresses their expression and restricts lymphoid lineage commitment (By similarity).
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.